Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic Ophiuroid Ophioderma longicaudum
1993; Taylor & Francis; Volume: 3; Issue: 3 Linguagem: Inglês
10.1080/10575639308043863
ISSN1057-5634
AutoresMaria Valeria D’Auria, Luigi Gomez Paloma, Luigi Minale, Raffaele Riccio, Angela Zampella, Mariella Morbidoni,
Tópico(s)Echinoderm biology and ecology
ResumoAbstract Two novel sulphated polyhydroxysteroids, 1, possessing potent cytotoxic activity, and 2, which proved to be cytoprotective against HIV-1, have been isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known tetrol disulphated 3. The structures of 1 and 2 have been determined to be cholest-5-ene-2α,3α,4β, 21-tetraol 3, 21-disulphate and cholest-5-ene-2β,3α, 21-triol 2, 21-disulphate, respectively.
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