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Glucose depletion hyperpolarizes guinea pig hippocampal neurons by an increase in potassium conductance

1988; Elsevier BV; Volume: 100; Issue: 1 Linguagem: Inglês

10.1016/0014-4886(88)90217-8

1090-2430

Andreas Spuler, W. Endres, P. Grafe,

Cardiac electrophysiology and arrhythmias

Superfusion of guinea pig hippocampal brain slices with a glucose-free solution induced a membrane hyperpolarization and an increase in input conductance of neurons in the CA3 region. Under voltage clamp, glucose depletion induced an outward current with a reversal potential near the K+ equilibrium potential. The action of glucose depletion was different from the effect of ouabain, indicating that low-glucose-induced changes in the membrane conductance are primarily due to alterations in cell metabolism rather than due only to an inhibition of the Na+K+ pump.