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Thoracolumbar Spinal Cord Compression Due to Vertebral Process Degenerative Joint Disease in a Family of Shiloh Shepherd Dogs

2003; Wiley; Volume: 17; Issue: 4 Linguagem: Inglês

10.1111/j.1939-1676.2003.tb02474.x

1939-1676

John McDonnell, Kim E. Knowles, Alexander de Lahunta, Jerold S. Bell, Charles T. Lowrie, Rory J. Todhunter,

Neurogenetic and Muscular Disorders Research

Journal of Veterinary Internal MedicineVolume 17, Issue 4 p. 530-537 Open Access Thoracolumbar Spinal Cord Compression Due to Vertebral Process Degenerative Joint Disease in a Family of Shiloh Shepherd Dogs John J. McDonnell, John J. McDonnell Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA DVM, MS, Neurology-Neu-rosurgery, Tufts University School of Veterinary Medicine, 200 West-boro Road, North Grafton, MA 01536; E-mail: jay.mcdonnell@tufts. eduSearch for more papers by this authorKim E. Knowles, Kim E. Knowles Veterinary Neurological Center, Phoenix, AZSearch for more papers by this authorAlexander de Lahunta, Alexander de Lahunta Department of Biomedical Sciences, Cornell University, Ithaca, NYSearch for more papers by this authorJerold S. Bell, Jerold S. Bell Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MASearch for more papers by this authorCharles T. Lowrie, Charles T. Lowrie Department of Small Animal Clinical Sciences, East Lansing, MISearch for more papers by this authorRory J. Todhunter, Rory J. Todhunter Department of Veterinary Clinical Sciences, Cornell University, Ithaca, NYSearch for more papers by this author John J. McDonnell, John J. McDonnell Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA DVM, MS, Neurology-Neu-rosurgery, Tufts University School of Veterinary Medicine, 200 West-boro Road, North Grafton, MA 01536; E-mail: jay.mcdonnell@tufts. eduSearch for more papers by this authorKim E. Knowles, Kim E. Knowles Veterinary Neurological Center, Phoenix, AZSearch for more papers by this authorAlexander de Lahunta, Alexander de Lahunta Department of Biomedical Sciences, Cornell University, Ithaca, NYSearch for more papers by this authorJerold S. Bell, Jerold S. Bell Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MASearch for more papers by this authorCharles T. Lowrie, Charles T. Lowrie Department of Small Animal Clinical Sciences, East Lansing, MISearch for more papers by this authorRory J. Todhunter, Rory J. Todhunter Department of Veterinary Clinical Sciences, Cornell University, Ithaca, NYSearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1939-1676.2003.tb02474.xCitations: 11 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Five young Shiloh Shepherd Dogs (4 males and 1 female) related by a common sire were studied because of progressive pelvic limb weakness and incoordination. All dogs had a spastic paraparesis and pelvic limb ataxia consistent with an upper motor neuron and general proprioceptive lesion between spinal cord segments T3 and L3. Proliferative lesions involving one or more of the articular processes from the 11th thoracic vertebrae to the 2nd lumbar vertebra were observed on radiographs of the thoracolumbar vertebrae. Dorsal compression of the spinal cord was identified during imaging studies at these sites. Abnormalities of the synovial joints and bony proliferation of the involved articular processes were identified at postmortem examination in 2 dogs. The articular processes and associated vertebral arches protruded into the vertebral canal, indenting the dorsal surface of the spinal cord. Degenerative joint disease (DJD) was identified histologically. A compressive myelopathy was diagnosed in the spinal cord. These dogs were affected by a compressive myelopathy as a consequence of vertebral process DJD that likely has a genetic component. The DJD could have been caused by a primary vertebral malformation or an injury to the processes at a young age causing malarticulation. References 1 Barber TM. The Origins of the Shiloh Shepherd in Word and Picture. Silver Springs , NY : International Shiloh Shepherd Registry; 1991. 2 LeCouteur RA, Grandy JL. Diseases of the spinal cord. In: SJ Ettinger, EC Feldman, ed. Veterinary Internal Medicine, 5th ed. Philadelphia , PA : WB Saunders; 2000: 608– 657. 3 Priester WA. Canine intervertebral disc disease: Occurrence by age, breed and sex among 8,117 cases. Theriogenology 1976; 6: 293– 301. 4 Kornegay JN. Discospondylitis. In: DH Slatter, ed. Textbook of Small Animal Surgery, 2nd ed. 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