Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival
2004; Elsevier BV; Volume: 213; Issue: 1 Linguagem: Inglês
10.1016/j.canlet.2004.03.004
ISSN1872-7980
AutoresRoss D. Farhadieh, Robert Smee, Kim Ow, Jia Lin Yang, Pamela J. Russell, Roger Crouch, P. Jackson, Ian Jacobson,
Tópico(s)Prostate Cancer Treatment and Research
ResumoOral Squamous Cell Carcinoma (OSCC) is a common malignancy. Treatment failure is mainly due to loco-regional disease recurrence. KAI1 is a newly discovered metastasis suppressor gene. Fifty-seven patients with primary OSCC underwent surgery alone or surgery and adjuvant radiotherapy. Immunohistochemical evaluation of KAI1/CD82 and p53 proteins was carried out on specimen obtained at surgery. Within neoplastic fields, KAI1/CD82 expression was downregulated and negative in 42/57 (73.7%) cases. p53 expression was positive in 26/57 (45.6%) cases. No correlation was noted between KAI1/CD82 and p53 expression or clinicopathological parameters. Univariate and multivariate Cox proportional hazard models showed a correlation between KAI1/CD82 expression with disease free survival (P=0.01, P=0.009) and overall survival (P=0.04, P=0.053) respectively.
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