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Cephalic ectodermal placodes and neurogenesis

1986; Elsevier BV; Volume: 9; Linguagem: Inglês

10.1016/0166-2236(86)90055-x

1878-108X

Nicole M. Le Douarin, Josiane Fontaine-Pérus, G Couly,

Axon Guidance and Neuronal Signaling

In the vertebrate embryo, the primary neural anlage, or neural plate, develops from the superficial ectoderm as a result of an inductive stimulus arising from the chordomesoderm. Although it is well established that the neural plate itself gives rise to CNS, the fate of those cells located at the junction of the neural and superficial ectoderm (also called neural ridges or neural folds), from which the neural crest and placodes are derived, has been the subject of controversy. Tracing these cells during ontogeny has been made possible by using the quail/chick chimaera system. Such studies have revealed the contribution of the neural ridge and the neurogenic placodes to various cephalic structures, and have allowed their relationships with the CNS to be followed from the early stages of neurulation throughout the whole period of morphogenesis.