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Sequential study of the IgA system in relapsing IgA nephropathy

1986; Elsevier BV; Volume: 30; Issue: 6 Linguagem: Inglês

10.1038/ki.1986.274

1523-1755

John Feehally, T. James Beattie, Paul Brenchley, Beatrice Coupes, Netar P. Mallick, Robert J. Postlethwaite,

Platelet Disorders and Treatments

Cellular and immunochemical parameters of the IgA system were studied in 15 subjects with IgA nephropathy (IgAN) and 15 agematched controls. In IgAN remission no abnormalities of the IgA system were detectable by the methods used. In IgAN relapse, [macroscopic hematuria associated with upper respiratory tract infection (URTI) (N = 6)] there were rises in IgA-bearing B-lymphocytes (three of six), T helper/suppressor cell ratio (six of six) and pokeweed mitogen-induced IgA production (four of six). Total serum and salivary IgA were unchanged. Serum IgA profile (HPLC-ELISA) showed increases in polymer IgA (three of six). No such changes were found during URTI in controls. These findings support the view that an exaggerated IgA response to mucosal antigen challenge initiates glomerular damage and hematuria in IgAN.