Portal de Periódicos da CAPES

Difficulty adhering to antidiabetic treatment: Factors associated with persistence and compliance

2013; Elsevier BV; Volume: 39; Issue: 3 Linguagem: Inglês

10.1016/j.diabet.2012.12.005

1878-1780

Line Guénette, Jocelyne Moisan, M.‐C. Breton, Caroline Sirois, Jean‐Pierre Grégoire,

Pharmaceutical Practices and Patient Outcomes

Aims. -This study aimed to assess the 1-year treatment persistence and compliance of new oral antidiabetic drug (OAD) users with their treatment, and to identify the factors associated with both persistence and compliance.Methods.-This population-based cohort study of new OAD users aged 18 years or above used the Quebec health insurance board databases.Those having a prescription filled for antidiabetic treatment during the period leading up to the 1-year anniversary of their first claim were considered to be persistent with their antidiabetic treatment.Of these patients, individuals with a medication possession ratio (MPR) greater or equal to 80% for OAD or insulin were deemed compliant.Also identified were the characteristics associated with both outcomes, using a multivariate logistic regression model.Results.-Our cohort consisted of 151,173 individuals, 119,832 (79.3%) of whom were considered persistent.Of these, 93,418 (78.0%) were also deemed compliant.Persistence and compliance were associated with older ages, living in a rural region, low socioeconomic status, having the first OAD prescribed by a general practitioner and a history of using five different drugs or more.People were less likely to be persistent and compliant if their initial OAD was a secretagogue and if they had consulted a physician eight times or more during the year prior to starting treatment.Conclusion. -One year after OAD treatment initiation, 21% had discontinued their treatment and 22% of those still being treated were non-compliant.These results could help to tailor interventions aimed at optimizing the use of OAD treatments.