A Transient N−O-Linked Pauson−Khand Strategy for the Synthesis of the Deschloro Carbocyclic Core of the Palau'amines and Styloguanidines
2003; American Chemical Society; Volume: 5; Issue: 13 Linguagem: Inglês
10.1021/ol0344063
ISSN1523-7060
AutoresStefan G. Koenig, Stefan M Miller, Kristi Leonard, Ralf S. Löwe, Betty C. Chen, David Austin,
Tópico(s)Chemical synthesis and alkaloids
ResumoA stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson-Khand cyclization of an enyne with a "transient N-O tether" to construct a five-membered carbocycle in a diastereoselective fashion. [reaction: see text]
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