A spinal opioid synapse mediates the interaction of spinal and brain stem sites in morphine analgesia
1982; Elsevier BV; Volume: 236; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(82)90036-1
ISSN1872-6240
AutoresJon D. Levine, Steven R. Lane, Newton C. Gordon, Howard L. Fields,
Tópico(s)Neuropeptides and Animal Physiology
ResumoThe interaction of spinal and brain stem opiate-sensitive sites was investigated using microinjection of morphine and naloxone into the fourth ventricle and lumbar subarachnoid space of the rat. Depending on the order of administration, spinal naloxone either partially or completely blocked the effect of ventricular morphine on both a spinal nociceptive reflex (tail-flick) and a complex nociceptive behavior (‘pain-induced’ vocalization). This suggests that the antinociceptive effects of ventricular morphine involve an endogenous opioid link at the level of the spinal cord.
Referência(s)