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BIBTEX RIS

Drug interaction with radiopharmaceuticals: a review

2005; Instituto de Tecnologia do Paraná (Tecpar); Volume: 48; Issue: spe2 Linguagem: Inglês

10.1590/s1516-89132005000700003

1678-4324

Mário Bernardo-Filho, Sebastião David Santos-Filho, Egberto Gaspar de Moura, Adalgisa Ieda Maiworm, Margarida Maria de Camões Orlando, M. E. Penas, Valbert Nascimento Cardoso, Luciana Camargo Bernardo, Lavínia de Carvalho Brito,

Medical Imaging Techniques and Applications

Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as radiation therapy, surgical procedures, prostheses, cardioversion, intubation, chemoperfusion, external massage, immunotherapy, blood transfusion and hemodialysis. In conclusion, the knowledge about these factors capable of interfering with the bioavailability of the radiobiocomplexes is worthwhile for secure diagnosis. Moreover, the development of biological models to study these phenomena is highly relevant and desirable.