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The effect of diterpenoidic diacylglycerols on tentacle regeneration in Hydra vulgaris

1991; Elsevier BV; Volume: 100; Issue: 3 Linguagem: Inglês

10.1016/0742-8413(91)90047-w

1878-1969

Luciano De Petrocellis, Vincenzo Di Marzo, Bruno Arcà, Margherita Gavagnin, Rosario Minei, Giuseppe Cimino,

Venomous Animal Envenomation and Studies

1. The effect of two ichthyotoxic diterpenoid diacylglycerols, verrucosins A and B, previously isolated from the mantle of a marine nudibranch mollusc, were studied on Hydra vulgaris tentacle regeneration. 2. A potent effect was found for both verrucosins in the low nanomolar range; the rank of potency observed was analogous to that reported for diglycerid activation of protein kinase C and to that found for verrucosin activation of this enzyme. 3. In the high nanomolar range, the two verrucosins were found to be toxic to Hydra vulgaris. 4. Verrucosin B-induced toxicity and tentacle regeneration were found to be dependent on [Ca2+] in the assay medium.