Gene structure of calcium‐dependent protease retains the ancestral organization of the calcium‐binding protein gene
1986; Wiley; Volume: 194; Issue: 2 Linguagem: Inglês
10.1016/0014-5793(86)80094-1
ISSN1873-3468
AutoresYasufumi Emori, Shigeo Ohno, M Tobita, Koichi Suzuki,
Tópico(s)Blood Coagulation and Thrombosis Mechanisms
ResumoThe gene structure of calcium‐dependent protease (Ca 2+ ‐protease) was determined. It comprises at least 21 exons, and these were assigned to the 4 functional domains of the protease. The protease domain does not show clear correlation between exons and functional units, but the calmodulin‐like calcium‐binding domain shows strong correlation. Each of the 4 consecutive calcium‐binding regions in the C‐terminal part of Ca 2+ ‐protease is encoded by one exon. This gene structure supports the idea that the 4 calcium‐binding regions of calcium‐binding proteins such as calmodulin arose by 2 steps of gene duplication.
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