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Citric Acid-based Hydroxyapatite Composite Scaffolds Enhance Calvarial Regeneration

2014; Nature Portfolio; Volume: 4; Issue: 1 Linguagem: Inglês

10.1038/srep06912

2045-2322

Dawei Sun, Yuhui Chen, Richard T. Tran, Song Xu, Denghui Xie, Chunhong Jia, Yuchen Wang, Ying Guo, Zhongmin Zhang, Jinshan Guo, Jian Yang, Dadi Jin, Xiaochun Bai,

Dental Implant Techniques and Outcomes

Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4 mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness and angiogenesis when compared to the control groups at 1, 3 and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic and off-shelf-available options in the repair of orthopedic defects.