Metabolism of arachidonic acid and prostaglandin synthesis in the preadipocyte clonal line OB17
1981; Elsevier BV; Volume: 98; Issue: 3 Linguagem: Inglês
10.1016/0006-291x(81)91178-5
ISSN1090-2104
AutoresRaymond Négrel, Gérard Ailhaud,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoBiosynthesis of prostaglandins in ob17 preadipose cells was studied in culture. Dihomo-γ-linolenic acid is exclusively converted to PGE1. Arachidonic acid behaves quantitatively as a more potent precursor, leading to the synthesis of PGE2 and 6-keto-PGF1α (stable product of prostacyclin). In all cases prostaglandin synthesis was confirmed directly by radioimmunoassay. This synthesis is maximal during the growth phase and decreases dramatically after confluence at a time where adipose conversion occurs, suggesting a possible relationship between both events.
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