Decreased striatal dopaminergic innervation in REM sleep behavior disorder
2000; Lippincott Williams & Wilkins; Volume: 55; Issue: 9 Linguagem: Inglês
10.1212/wnl.55.9.1410
ISSN1526-632X
AutoresRoger L. Albin, Robert A. Koeppe, Ronald D. Chervin, Flavia B. Consens, K. Wernette, Kirk A. Frey, Michael S. Aldrich,
Tópico(s)Genetic Neurodegenerative Diseases
ResumoArticle abstract—REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [ 11 C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [ 11 C]dihydrotetrabenazine binding, particularly in the posterior putamen.
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