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Physical training improves insulin resistance syndrome markers in obese adolescents

2002; Lippincott Williams & Wilkins; Volume: 34; Issue: 12 Linguagem: Inglês

10.1097/00005768-200212000-00010

1530-0315

Hyun‐Sik Kang, Bernard Gutin, Paule Barbeau, Scott Owens, Christian R. Lemmon, Jerry D. Allison, Mark S. Litaker, Ngoc‐Anh Le,

Diabetes, Cardiovascular Risks, and Lipoproteins

KANG, H.-S., B. GUTIN, P. BARBEAU, S. OWENS, C. R. LEMMON, J. ALLISON, M. S. LITAKER, and N.-A. LE. Physical training improves insulin resistance syndrome markers in obese adolescents. Med. Sci. Sports Exerc., Vol. 34, No. 12, pp. 1920–1927, 2002. Introduction The purpose of this study was to test the hypothesis that physical training (PT), especially high-intensity PT, would have a favorable effect on components of the insulin resistance syndrome (IRS) in obese adolescents. Methods Obese 13- to 16-yr-olds (N = 80) were randomly assigned to one of the following 8-month interventions; 1) lifestyle education (LSE)-alone every 2 wk, 2) LSE+moderate-intensity PT, and 3) LSE+high-intensity PT. PT was offered 5 d·wk−1. Plasma triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very low-density lipoprotein cholesterol (VLDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein (low density lipoprotein (LDL)) particle size, apolipoproteins AI and B, glucose, insulin, and blood pressure were measured with standardized methods. Results The intent-to-treat analyses for all subjects who completed pre- and post-tests regardless of their adherence to the interventions showed that the LSE+high-intensity PT group had more favorable changes than the LSE-alone group in TAG level (P = 0.012), TC/HDLC (P = 0.013), and diastolic blood pressure (P = 0.031). For efficacy analyses, all PT subjects who attended at least 2 d·wk−1 (40%) were combined into one group (LSE+PT) and compared with the LSE-alone group. These two-group analyses showed significant interactions (P < 0.001) between baseline values and group membership for ΔTAG, ΔVLDLC, and ΔTC/HDLC, such that subjects who had the least favorable baseline values showed the most beneficial impact of the PT. Of particular interest was a favorable effect of the PT on LDL particle size. Conclusion PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.