Portal de Periódicos da CAPES

Neurodegenerative diseases of Guam: Analysis of TAU

1999; Lippincott Williams & Wilkins; Volume: 53; Issue: 2 Linguagem: Inglês

10.1212/wnl.53.2.411

1526-632X

Jordi Pérez‐Tur, Luc Buée, Huw R. Morris, Stephen C. Waring, Luisa Onstead, Fabienne Wavrant‐De Vrièze, Richard Crook, Valérie Buée‐Scherrer, Patrick R. Hof, Ronald Petersen, Patrick L. McGeer, André Delacourte, M. Hutton, Teepu Siddique, J. Eric Ahlskog, John Hardy, John C. Steele,

Lysosomal Storage Disorders Research

Article abstract Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam.