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Discovery-Based Science Education: Functional Genomic Dissection in Drosophila by Undergraduate Researchers

2005; Public Library of Science; Volume: 3; Issue: 2 Linguagem: Inglês

10.1371/journal.pbio.0030059

1545-7885

Jiong Chen, Gerald B. Call, Elsa Beyer, Chris Bui, Albert Cespedes, Amy Y. Y. Chan, Jenny Chan, Stacy Chan, Akanksha Chhabra, Peter Dang, Artemis Deravanesian, Brenda Hermogeno, James Jen, Eunha Kim, Eric Lee, Gemma Lewis, Jamie L. Marshall, Kirsten Regalia, Farnaz Shadpour, Aram Shemmassian, Kristin Spivey, Maggie Wells, Joy Wu, Yuki Yamauchi, Amir Yavari, Anna Abrams, Amanda Abramson, L. Valiña Amado, Jenny Anderson, Keenan Bashour, Елена Бибикова, Allen Bookatz, Sarah Brewer, Natalie Buu, Stephanie Calvillo, Joseph Cao, Aileen Chang, Daniel Chang, Yu-Li Chang, Yibing Chen, Joo Hee Choi, Jeyling Chou, Sumit Datta, Ardalan Davarifar, Poonam Desai, J.I. Fabrikant, Shahbaz Farnad, Katherine Fu, E. Muñoz García, Nick Garrone, Srpouhi Gasparyan, Phyllis Gayda, Chad Goffstein, Courtney E. Gonzalez, Mariam Guirguis, Ryan Hassid, Aria Hong, Julie Hong, Lindsay Hovestreydt, Charles Hu, Farid Jamshidian, Katrin Kahen, Linda Kao, Melissa M. Kelley, T. H. Kho, Sarah Kim, Yein Kim, Brian Kirkpatrick, E. Kohan, Robert Kwak, Adam D. Langenbacher, Santino Laxamana, Chris Lee, Janet Lee, So-Youn Lee, To Hang S Lee, Toni Lee, Sheila Lezcano, Henry Lin, Peter Lin, Julie Luu, Thanh Luu, Will Marrs, Erin Marsh, Sarah Min, Tanya Minasian, Amit Misra, Miles Morimoto, Yasaman Moshfegh, Jessica C. Murray, Cynthia Nguyen, Kha Nguyen, Ernesto Nodado, Amanda O'Donahue, Ndidi Onugha, Nneka Orjiakor, Bhavin Padhiar, Mara Pavel-Dinu, Alex Pavlenko, E. ANTONIO PAZ, Sarah Phaklides, Lephong Pham, Preethi Poulose, Russell Powell, Aya D. Pusic, Divi Ramola, Meghann Ribbens, Bassel Rifai, Desiree Rosselli, Manyak Saakyan, Pamela Saarikoski, Miriam Segura, Ramnik Singh, Vivek Singh, Emily Skinner, Daniel Solomin, Kosha Soneji, Erika Stageberg, Marina Stavchanskiy, Leena Tekchandani, Leo Thai, Jayantha Thiyanaratnam, Maurine Tong, Aneet Toor, Steve Tovar, Kelly Trangsrud, Wah-Yung Tsang, Marc Uemura, Mary Unkovic, Emily Vollmer, Emily S. Weiss, Damien Wood, Sophia Wu, Winston Wu, Qing Xu, Kevin Yackle, Will Yarosh, Laura Yee, George Yen, Grant Alkin, Sheryllene Go, Devon M Huff, Helena Minye, Eric Paul, Nikki Villarasa, Allison B. Milchanowski, Utpal Banerjee,

Genomics and Phylogenetic Studies

T he excitement of scientifi c research and discovery cannot be fully conveyed by didactic lectures alone.Several recent initiatives and proposals, therefore, have supported a more participatory, discovery-based instruction for undergraduate science education [1,2].In functional genomics, we have found an ideal platform to simultaneously benefi t students and contribute to scientifi c discovery.The sequencing of eukaryotic genomes has facilitated the identifi cation of complete sets of genes in humans and model genetic organisms.This has allowed many forms of high-throughput analyses of transcriptional profi les, protein interactions, structural motifs, and even genome-wide knock-downs in cell lines or in selected organisms.However, one of the best tools to provide functional information about gene actionobtaining in vivo evidence about the phenotype resulting from heritable loss of function-is diffi cult and less amenable to high-throughput research.We were able to achieve a large-scale in vivo analysis with a signifi cant number