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Effects of Lead Exposure on Bromocriptine‐Induced Penile Erection in Rats

1997; Wiley; Volume: 81; Issue: 2 Linguagem: Inglês

10.1111/j.1600-0773.1997.tb00035.x

1600-0773

Mahmoud Ghazi‐Khansari, Ismaeel Heidari, Mohammad‐Reza Zarrindast,

Prenatal Substance Exposure Effects

Abstract: In the present work we have studied the effects of lead exposure on penile erection induced by bromocriptine. Intraperitoneal injection of bromocriptine (2, 3, 4 and 8 mg/kg) induced dose‐related penile erection in rats. Maximum response was observed with 4 mg/kg of the drug. Lead exposure (as Pb‐acetate in drinking water) for periods of 7, 14, 21 and 28 days decreased the bromocriptine‐induced penile erection response. Higher concentrations of lead (0.05%) were shown to cause a more prominent decrease of penile erection. The same procedure for lead administration did not significantly alter penile erection induced by physostigmine (0.1 and 0.3 mg/kg, intraperitoneally). In a series of experiments, blood lead concentrations were measured 7 and 21 days after lead exposure. Significant increases of lead concentrations were found after lead exposure. It is concluded that lead can influence bromocriptine‐induced penile erection.