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96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

2008; Bentham Science Publishers; Volume: 5; Issue: 7 Linguagem: Inglês

10.2174/157018008785909840

1875-628X

T. Heikkilä, Leena Peltonen, Saila Taskinen, Timo Laaksonen, Jouni Hirvonen,

Drug Solubulity and Delivery Systems

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing. Keywords: Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate