Diagnostic Efficacy of Conventional as Compared to Liquid-Based Cytology in Thyroid Lesions
2009; Karger Publishers; Volume: 53; Issue: 6 Linguagem: Inglês
10.1159/000325407
ISSN1938-2650
AutoresEsther Diana Rossi, Marco Raffaelli, Gian Franco Zannoni, Alfredo Pontecorvi, Antonino Mulè, Cinzia Callà, Celestino Pio Lombardi, Guido Fadda,
Tópico(s)Thyroid Cancer Diagnosis and Treatment
ResumoTo evaluate the efficacy of thyroid fine needle aspiration cytology (FNAC) processed by liquid-based cytology (LBC) as compared to conventional smears (CS) in 10,360 consecutive cases in 3 reference periods.In 1997-1998, 2,394 FNACs had CS; in 2001-2002, 3,463 had both CS and LBC; and in 2004-2005, 4,503 had only LBC. Three arbitrary parameters of efficacy were chosen to compare the two different methods: rate of inadequacy (IR), rate of indeterminacy (INDR) and rate of malignancy (MR). In the same biennia 6,184 thyroidectomy specimens were examined.IR was, respectively, 8.4% in 1997-1998, 18.4% in 2001-2002 and 13.3% in 2004-2005. MR was respectively 2.2%, 2.5% and 2.2%. INDR was 16.6% in 1997-1998, 23.3% in 2001-2002 and 15.9% in 2004-2005. In each biennium, respectively, 16.9%, 27.6% and 28% of malignant neoplasms were histologically diagnosed.LBC was used as an alternative method in the cytologic diagnosis for the preoperative selection of thyroid neoplasms, decreasing indeterminate diagnoses without MR changes.
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