Altered expression of the synuclein family mRNA in Lewy body and Alzheimer’s disease
2001; Elsevier BV; Volume: 914; Issue: 1-2 Linguagem: Inglês
10.1016/s0006-8993(01)02772-x
ISSN1872-6240
AutoresEdward Rockenstein, Lawrence A. Hansen, Margaret Mallory, John Q. Trojanowski, Douglas Galasko, Eliezer Masliah,
Tópico(s)Nuclear Receptors and Signaling
ResumoThe main objective of this study was to determine if levels of α-, β- and/or γ-synuclein mRNAs are differentially affected in brains of Lewy body disease (LBD) and Alzheimer’s disease (AD) patients, compared to controls. In control cases, highest levels of expression were observed in the neocortex and the lowest in basal ganglia and substantia nigra. β-Synuclein was the most abundant message (75–80%), followed by γ-synuclein (10–15%) and α-synuclein (8–10%). Analysis of the superior temporal cortex, a region selectively affected in LBD and AD, showed that compared to controls, levels of α-synuclein were increased in cases of diffuse LBD (DLBD), levels of β-synuclein were decreased in AD and DLBD, and levels of γ-synuclein were increased in AD cases. This study suggests that a critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders.
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