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BIBTEX RIS

Isolamento e atividades biológicas de produtos naturais das esponjas monanchora arbuscula, aplysina sp. petromica ciocalyptoides e topsentia ophiraphidites, da ascídia didemnum ligulum e do octocoral carijoa riisei

2007; Brazilian Chemical Society; Volume: 30; Issue: 5 Linguagem: Inglês

10.1590/s0100-40422007000500027

ISSN

1678-7064

Autores

M. H. Kossuga, Simone Possedente de Lira, Andréa Mendes do Nascimento, M.T.P. Gambardella, Roberto G. S. Berlinck, Yohandra Reyes Torres, Gislene G. F. Nascimento, Eli F. Pimenta, Márcio Luís Andrade e Silva, Otávio Henrique Thiemann, Glaucius Oliva, André G. Tempone, Márcia de Souza Carvalho Melhem, Ana Olı́via de Souza, Fábio C. S. Galetti, Célio Lopes Silva, Bruno C. Cavalcanti, Cláudia Pessoa, Manoel Odorico de Moraes, Eduardo Hajdu, Solange Peixinho, Rosana Moreira da Rocha,

Tópico(s)

Marine Sponges and Natural Products

Resumo

ASCIDIAN Didemnum ligulum AND FROM THE OCTOCORAL Carijoa riisei.The investigation of extracts from six species of marine invertebrates yielded one new and several known natural products.Isoptilocaulin from the sponge Monanchora aff.arbuscula displayed antimicrobial activity at 1.3 μg/mL against an oxacillin-resistant strain of Staphylococcus aureus.Five inactive known dibromotyrosine derivatives, 2 -6, were isolated from a new species of marine sponge, Aplysina sp.The sponges Petromica ciocalyptoides and Topsentia ophiraphidites yielded the known halistanol sulfate A (7) as an inhibitor of the antileishmanial target adenosine phosphoribosyl transferase.The ascidian Didemnum ligulum yielded asterubin (10) and the new N, N-dimethyl-O-methylethanolamine (11).The octocoral Carijoa riisei yielded the known 18-acetoxypregna-1,4,20-trien-3-one (12), which displayed cytotoxic activity against the cancer cell lines SF295, MDA-MB435, HCT8 and HL60.

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