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Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single‐Step Process

2009; Volume: 21; Issue: 18 Linguagem: Inglês

10.1002/adma.200800382

1521-4095

Wenxin Wang, Liang He, Racha Cheikh Al Ghanami, Lloyd Hamilton, Michael Fraylich, Kevin M. Shakesheff, Brian R. Saunders, Cameron Alexander,

Polymer Surface Interaction Studies

Surface-engineered microparticles with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free-flowing dispersions below 37 °C, but form porous space-filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.