Mannich reactions of π-excessive heterocycles using bis-(dialkylamino)methanes and alkoxydialkylaminomethanes activated with acetyl chloride or sulphur dioxide
1988; Elsevier BV; Volume: 29; Issue: 24 Linguagem: Inglês
10.1016/0040-4039(88)85070-6
ISSN1873-3581
AutoresStephen C. Eyley, Harry Heaney, George Papageorgiou, Robert F. Wilkins,
Tópico(s)Chemical Reaction Mechanisms
ResumoΠ-Excessive heterocycles react rapidly with bis(dialkylamino)methanes (aminals) and alkoxydialkylaminomethanes (aminol ethers) in acetonitrile to afford Mannich bases in good yields when activated by means of an acidic reagent such as acetyl chloride or sulphur dioxide: the principal compound studied was N-methylpyrrole.
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