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Anti-inflammatory activity of Motherwort ( Leonurus sibiricus L.)

2008; Taylor & Francis; Volume: 31; Issue: 2 Linguagem: Inglês

10.1080/08923970802135443

1532-2513

Hye‐Young Shin, Sang‐Hyun Kim, Sin-Myoung Kang, Ik-Jun Chang, Sang-Yong Kim, Hoon Jeon, Kang‐Hyun Leem, Won‐Hwan Park, Jong‐Pil Lim, Tae‐Yong Shin,

Dermatology and Skin Diseases

Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-α, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-κB activation in HMC-1 cells, which was inhibited by MW (1 mg/ml). MW inhibited secretion of TNF-α, IL-6, and IL-8 possibly by inhibiting NF-κB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.