A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night
1983; Elsevier BV; Volume: 89; Issue: 1-2 Linguagem: Inglês
10.1016/0014-2999(83)90622-2
ISSN1879-0712
AutoresAlexander A. Borbély, P Mattmann, M Loepfe, Isabel Fellmann, Margaret Gerne, Inge Strauch, Dietrich Lehmann,
Tópico(s)Sleep and related disorders
ResumoAll-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the frequency range of sleep spindles. In the subsequent drug-free night, the latter changes were no longer present after triazolam, whereas the reduction of slow wave activity persisted after all compounds.
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