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Blood flow in skin, subcutaneous adipose tissue and skeletal muscle in the forearm of normal man during an oral glucose load

1987; Wiley; Volume: 130; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1987.tb08189.x

1365-201X

Jens Bülow, Arne Astrup, Niels Juel Christensen, Jens Kastrup,

Cardiovascular and exercise physiology

Blood flow in skin, subcutaneous adipose tissue and skeletal muscle in the forearm of normal man during an oral glucose load. Acta Physiol Scand 130, 657–661. Received 7 November 1986, accepted 8 March 1987. ISSN 00014772. Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital and Hvidovre Hospital, Department of Medical Endocrinology, Hvidovre Hospital, and Department of Medical Endocrinology, Herlev Hospital, Copenhagen, Denmark. Blood flow to the forearm, and the subcutaneous tissue and skin in the forearm were measured by strain gauge plethysmography, 133 Xe‐elimination and Laser Doppler flowmetry during an oral glucose load (I g glucose kg ‐I lean body mass) and during control conditions. The forearm blood flow remained constant during both experiments. Glucose induced a two‐fold vasodilatation in subcutaneous tissue. In skin, glucose induced a relative vasodilatation and later a relative vasoconstriction compared with control experiments. When estimated from forearm blood flow and subcutaneous and skin blood flows, muscle blood flow decreased about 20–30% during both experiments. Proximal nervous blockade did not abolish the glucose‐induced vasodilatation in subcutaneous tissue. In the glucose experiment, arterial glucose concentration increased to 7.8 ±1.17 mmol 1 ‐ ‐ 1 30min after the load was given and then decreased to 4.5 ±0.34 mmol 1 ‐ ‐ 1 at the end of the experiment. In the control experiments glucose concentration was constant. Arterial noradrenaline concentration increased significantly from 1.0±0.13 to about 1.5±0.3 nmol 1 ‐ ‐ 1 120 min after glucose and remained at this level during the experiment. Similarly adrenaline increased from 0.16 ±0.11 to about 0.4 ±o.16 nmol I ‐1 180 min after glucose. It is hypothetized that the vasodilating effect of glucose in subcutaneous tissue is secondary to metabolic events connected to glucose uptake and energy deposition in adipose tissue.