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Regulation of membrane type-matrix metalloproteinases

2002; Elsevier BV; Volume: 12; Issue: 2 Linguagem: Inglês

10.1006/scbi.2001.0421

1096-3650

Sonia Hernandez‐Barrantes, Margarida Bernardo, Márta Tóth, Rafael Fridman,

Blood Coagulation and Thrombosis Mechanisms

Pericellular proteolysis is a hallmark of tumor cell metastasis. The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a distinctive group of membrane-bound MMPs that are central mediators of surface proteolytic events that regulate tumor cell motility, metastasis and angiogenesis. As membrane-tethered proteases, the MT-MMPs exhibit unique regulatory mechanisms and interactions with metalloproteinase inhibitors and other relevant molecules. This review will focus on new emerging information on the mechanisms that regulate MT-MMP processing, activity and inhibition , and their significance for enzyme function in the tumor microenvironment.