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Tumor necrosis factor alpha −238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes

2013; Elsevier BV; Volume: 99; Issue: 3 Linguagem: Inglês

10.1016/j.diabres.2012.12.007

1872-8227

Deep Dutta, Subhadip Choudhuri, Samim Ali Mondal, Indira Maisnam, Abu Hena Hasanoor Reza, Sujoy Ghosh, Subhankar Chowdhury, Basudev Bhattacharya, Satinath Mukhopadhyay,

Diabetes, Cardiovascular Risks, and Lipoproteins

Prediabetes (IPD; n = 122) and normoglycemic individuals (n = 100) underwent assessment of polymorphisms of TNFα (−238, −308) and IL6 (−174). After 27.25 ± 5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNFα −238AA/GA genotypes were significantly more common in IPD, had higher TNFα, higher progression to diabetes and lower reversal.