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SERUM LEVELS OF TSH, T3, rT3, T4 AND T3-RESIN UPTAKE IN SURGICAL TRAUMA

1978; Oxford University Press; Volume: 88; Issue: 3 Linguagem: Inglês

10.1530/acta.0.0880482

1479-683X

H.-O. Adami, H. Johansson, L Thorén, Leif Wide, Göran Åkerström,

Thyroid Cancer Diagnosis and Treatment

ABSTRACT Changes in thyroid hormone metabolism induced by surgical trauma were studied by determination of TSH, T 3 , rT 3 , T 4 and T 3 -resin uptake before, during and after mastectomy in 20 women and cholecystectomy in 10 women. Pronounced and reciprocal changes, explained by altered peripheral T 4 metabolism were found concerning T 3 and rT 3 . The decreased T 3 and increased rT 3 -levels approached or exceeded the limits of the reference range on the first post-operative day. A significant increase in T 3 -resin uptake and a decrease in serum T 4 were already observed during surgery and probably was caused by a decreased protein binding capacity. An increased concentration of TSH in the serum during surgery was followed by a significant post-operative decrease, possibly due to a suppressive effect of endogenous cortisol. No obvious difference in absolute values or the pattern of change was found between the mastectomy and cholecystectomy groups, although a somewhat more pronounced and retarded alteration in rT 3 was found after cholecystectomy.