Infection and AIDS in Adult Macaques After Nontraumatic Oral Exposure to Cell-Free SIV
1996; American Association for the Advancement of Science; Volume: 272; Issue: 5267 Linguagem: Inglês
10.1126/science.272.5267.1486
ISSN1095-9203
AutoresTimothy W. Baba, Anita M. Trichel, An Li, Vladimír Liška, Louis N. Martin, Michael Murphey‐Corb, Ruth M. Ruprecht,
Tópico(s)HIV/AIDS oral health manifestations
ResumoUnprotected receptive anal intercourse is a well-recognized risk factor for infection with human immunodeficiency virus-type 1 (HIV-1). Isolated human case reports have implicated HIV-1 transmission by oral-genital exposure. Adult macaques exposed nontraumatically to cell-free simian immunodeficiency virus (SIV) through the oral route became infected and developed acquired immunodeficiency syndrome (AIDS). The minimal virus dose needed to achieve systemic infection after oral exposure was 6000 times lower than the minimal dose required to achieve systemic infection after rectal exposure. Thus, unprotected receptive oral intercourse, even in the absence of mucosal lesions, should be added to the list of risk behaviors for HIV-1 transmission.
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