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Mutagenicity of epichlorohydrin in the bacterial assay system: evaluation by direct in vitro activity and in vivo activity of urine from exposed humans and mice

1978; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês

10.1016/0165-1161(78)90390-4

1878-7088

D.J. Kilian, Terry G. Pullin, Tim Connor, Marvin S. Legator, Harley Edwards,

Carcinogens and Genotoxicity Assessment

Epichlorohydrin (ECH) is one of the more commercially important aliphatic epoxides used extensively as an industrial intermediate, a laboratory reagent, and as an insecticide. It is a volatile, colourless liquid with an ethereal odour. It behaves as an alkylating agent. Reports have shown it to cause the respiratory and dermal toxicity in animals and humans. It has also been reported to be carcinogenic in experimental models. Thus, the wide-spread use of this aliphatic epoxide is of great concern in human health problem. The purpose of this paper is to critically review and update the mutagenic and clastogenic effects of ECH based on available literature.