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Anti-nociceptive and anti-inflammatory activity of sophocarpine

2009; Elsevier BV; Volume: 125; Issue: 2 Linguagem: Inglês

10.1016/j.jep.2009.06.036

1872-7573

Yonglin Gao, Guisheng Li, Chunmei Li, Xiaoyin Zhu, Min Li, Chaolin Fu, Bafang Li,

Bioactive Compounds and Antitumor Agents

This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study. Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg). Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.