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Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system

1976; Wiley; Volume: 38; Issue: 4 Linguagem: Inglês

10.1002/1097-0142(197610)38

1097-0142

Kenneth D. Herbst, Michael P. Corder, Glen R. Justice,

Glioma Diagnosis and Treatment

CancerVolume 38, Issue 4 p. 1476-1478 ArticleFree Access Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system Kenneth D. Herbst MD, Corresponding Author Kenneth D. Herbst MD Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Assistant Chief, Hematology-Oncology Service, Department of Medicine, Fitzsimons Army Medical Center, Denver, CO 80240.Assistant Chief, Hematology-Oncology Service, Department of Medicine, Fitzsimons Army Medical Center, Denver, CO 80240===Search for more papers by this authorMichael P. Corder MD, FACP, Michael P. Corder MD, FACP Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Director, Oncology Section, Division of Hematology-Oncology, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, IO 52242.Search for more papers by this authorGlen R. Justice MD, Glen R. Justice MD Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Chief, Oncology Service, Department of Medicine, Letterman Army Medical Center, Presidio of San Francisco, CA 94129.Search for more papers by this author Kenneth D. Herbst MD, Corresponding Author Kenneth D. Herbst MD Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Assistant Chief, Hematology-Oncology Service, Department of Medicine, Fitzsimons Army Medical Center, Denver, CO 80240.Assistant Chief, Hematology-Oncology Service, Department of Medicine, Fitzsimons Army Medical Center, Denver, CO 80240===Search for more papers by this authorMichael P. Corder MD, FACP, Michael P. Corder MD, FACP Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Director, Oncology Section, Division of Hematology-Oncology, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, IO 52242.Search for more papers by this authorGlen R. Justice MD, Glen R. Justice MD Department of Hematology-Oncology, Letter-man Army Medical Center, Presidio of San Francisco, California Chief, Oncology Service, Department of Medicine, Letterman Army Medical Center, Presidio of San Francisco, CA 94129.Search for more papers by this author First published: October 1976 https://doi.org/10.1002/1097-0142(197610)38:4 3.0.CO;2-JCitations: 59 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Primary lymphoma of the central nervous system (CNS) is extremely rare. A case of mixed histiocytic lymphocytic lymphoma of the CNS that initially occurred in the spinal cord is reported. Multicentric recurrence following radiotherapy was successfully treated with intrathecal methotrexate and the patient remains free of disease after 4 years. The role of intrathecal methotrexate as alternative therapy following irradiation failure is discussed. References 1 Duttera, M. J., Bleyer, W. A., Pomeroy, T. C., et al.: Irradiation, methotrexate toxicity, and the treatment of meningeal leukemia. Lancet 2: 703–707, 1973. 2 Freeman, C., Berg, J. W., and Cutler, S. J.: Occurrence and prognosis of extra-nodal lymphomas. Cancer 29: 252–260, 1972. 3 Fuks, A., and Kaplan, H. S.: Recurrence rates following radiation therapy of nodular and diffuse malignant lymphomas. Radiology 108: 675–684, 1973. 4 Hanbery, J. W., and Dugger, G. S.: Perithelial sarcoma of the brain. Arch. Neurol. 71: 732–761, 1954. 5 Henry, J. N., Heffner, R. R. Jr., Dillard, S. 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