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THE DIFFERENTIAL DIAGNOSIS OF THE LEUKEMIC STATES

1935; American Medical Association; Volume: 104; Issue: 9 Linguagem: Inglês

10.1001/jama.1935.02760090001001

2376-8118

Roy R. Kracke, Hortense Elton Garver,

Myeloproliferative Neoplasms: Diagnosis and Treatment

A thorough knowledge of hematopoiesis is essential for a careful differentiation of the various types of leukemia. No longer are these dyscrasias considered "diseases of the blood" but rather dysfunctions of hematopoietic tissues. 1 Until the second decade of the twentieth century with the work of Reschad and Schilling-Torgau 2 and others, there were recognized only two types of leukemia: myeloid, arising in the bone marow, and lymphatic, having its origin in the lymphoid tissue. The recognition of a third type of leukemia involving the monocytic series of cells has engendered new ideas concerning the origin and classification of blood cells. 3 As a result of this stimulus, many conflicting theories have arisen. PRESENT CONCEPTION OF HEMATOPOIESIS Investigators are in accord only in a single concept— that all blood cells have their origin from the mesenchymal cell of the mesodermal layer in the embryo. 4 From this point, opinions diverge