Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients
1997; Elsevier BV; Volume: 133; Issue: 3 Linguagem: Inglês
10.1016/s0002-8703(97)70229-1
ISSN1097-6744
AutoresSong Wan, Jean-Louis LeClerc, Denis Schmartz, Luc Barvais, Chi-Hoang Huynh, Jacques Devière, Jean-Marie DeSmet, Jean‐Louis Vincent,
Tópico(s)Cardiac, Anesthesia and Surgical Outcomes
ResumoWith its antiinflammatory properties, interleukin (IL)–10 may play an important role in limiting complications associated with cardiopulmonary bypass (CPB). We previously demonstrated that pretreatment with steroids can significantly increase IL-10 production during CPB, but neither the heart nor the lung was found to be its main source. To define whether the liver is the source of IL-10, hepatic venous cannulation was performed in 12 patients undergoing CPB. Each patient received 30 mg/kg of methylprednisolone before operation. Plasma levels of IL-10 were simultaneously measured in peripheral arterial blood and hepatic venous blood before heparin administration, before aortic cross-clamping, and 5, 30, 60, 90, and 120 minutes after aortic declamping. The duration of CPB and aortic cross-clamping was 113 ± 7 minutes and 75 ± 6 minutes (mean ± SEM), respectively. IL-10 levels 30 minutes after declamping were significantly higher in hepatic venous blood than in arterial blood (1187 ± 573 pg/ml vs 911 ± 405 pg/ml, p < 0.01 by Wilcoxon's signed-rank test). To determine whether steroids can also induce the release of another antiinflammatory cytokine, IL-4, plasma IL-4 levels were measured simultaneously. IL-4 was detected in the arterial blood of only 4 of the 12 patients, transiently after aortic declamping. IL-4 was not detected in hepatic venous blood. In conclusion, the liver is a major source of IL-10 during CPB. However, steroid-treated patients do not show an increase in IL-4, and the liver is not the source of IL-4 during and after CPB. (Am Heart J 1997;133:335-9.)
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