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Biotinated Probe Containing a Long-Terminal Repeat Hybridized to a Mouse Colon Tumor and Normal Tissue

1983; American Association for the Advancement of Science; Volume: 222; Issue: 4630 Linguagem: Inglês

10.1126/science.6689218

1095-9203

Moira E. Royston, Leonard H. Augenlicht,

Genomics and Chromatin Dynamics

The cloned complementary DNA pMCT-1, which contains an intracisternal A particle long-terminal repeat, is more highly expressed in a mouse colon tumor than in the normal mouse colon. In situ hybridization of biotin-substituted pMCT-1 to fixed frozen sections shows that expression of pMCT-1 is seen throughout the tumor and is highly heterogeneous on a cellular basis, while expression is undetectable in any cell in the normal colonic mucosa.