A novel antimicrobial peptide from the sea hare Dolabella auricularia
2003; Elsevier BV; Volume: 27; Issue: 4 Linguagem: Inglês
10.1016/s0145-305x(02)00105-2
ISSN1879-0089
AutoresRyosuke Iijima, Jun Kisugi, Masatoshi Yamazaki,
Tópico(s)Protein Hydrolysis and Bioactive Peptides
ResumoThe sea hare Dolabella auricularia is a marine shell-less gastropod. Four cytotoxic glycoproteins named dolabellanin A, C, E and P were found in the animal previously. An antimicrobial factor was newly isolated from the sea hare's body-wall including skin and mucus. This factor is a novel peptide which consists of 33 amino acid residues, and is called dolabellanin B2. Dolabellanin B2 was cytotoxically effective against some pathogenic microorganisms at a concentration of 2.5–100 μg/ml.
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