Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus
2000; American Society for Microbiology; Volume: 74; Issue: 20 Linguagem: Inglês
10.1128/jvi.74.20.9786-9791.2000
ISSN1098-5514
AutoresShin-ichi Yanagawa, Jong-Seo Lee, Kazuhiro Kakimi, Yukihiro Matsuda, Tasuku Honjo, Akinori Ishimoto,
Tópico(s)RNA Research and Splicing
ResumoIn contrast to wild-type mouse mammary tumor virus (MMTV), the MMTV mutants with specific deletions in the U3 region of their long terminal repeats cause T-cell lymphomas. In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV proviruses were integrated into a short region of the Notch1 genome, so that truncated Notch1 transcripts encoding the transmembrane and the cytoplasmic domains of Notch1 protein could be expressed. Thus, Notch1 is a major target of provirus insertional mutagenesis in these T-cell lymphomas.
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