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Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

2014; National Academy of Sciences; Volume: 111; Issue: 30 Linguagem: Inglês

10.1073/pnas.1411413111

1091-6490

Jirka Grosse, Helen Heffron, Keith Burling, Mohammed Akhter Hossain, Abdella M. Habib, Gareth J. Rogers, Paul Richards, Rachel Larder, Debra Rimmington, Alice E. Adriaenssens, Laura E. Parton, Justin Powell, Matteo Binda, William H Colledge, Joanne Doran, Yukio Toyoda, John D. Wade, Samuel Aparício, Mark Carlton, Anthony P. Coll, Frank Reimann, Stephen O’Rahilly, Fiona M. Gribble,

Pancreatic function and diabetes

Significance Hormonal factors from specialized enteroendocrine cells in the gut epithelium link the availability of dietary nutrients to energy utilization and storage. Many gut hormones also affect behaviors such as appetite and foraging, conveying for example the satiating effects of food consumption. Here we identify insulin-like peptide 5 (Insl5) as a product of colonic endocrine L-cells, and show that levels were elevated in calorie-restricted mice and reduced after feeding. Consistent with this profile Insl5 administration stimulated food intake in mice, indicating it should join ghrelin as only the second identified gut hormone that enhances appetite. Modulating the Insl5 axis presents a new strategy for the treatment of metabolic disease and obesity.