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Tanzawaic Acids A, B, C, and D: Inhibitors of Superoxide Anion Production from Penicillium citrinum

1997; Oxford University Press; Volume: 26; Issue: 9 Linguagem: Inglês

10.1246/cl.1997.885

1348-0715

Makoto Kuramoto, Kaoru Yamada, Mayumi Shikano, Kazunaga Yazawa, Hirokazu Arimoto, Tomoyuki Okamura, Daisuke Uemura,

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Abstract Tanzawaic acids have been isolated from Penicillium citrinum and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analyses of 1H–1H coupling constants and NOE data. Tanzawaic acid B (GS-1302-1) significantly inhibits superoxide anion production in human neutrophils.