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BIBTEX RIS

Pyridinic analog of the natural product (−)-spectaline as potential adjuvant for the treatment of central nervous system disorders

2015; Elsevier BV; Volume: 25; Issue: 10 Linguagem: Inglês

10.1016/j.bmcl.2015.02.050

ISSN

1464-3405

Autores

Marília Valli, Andresa Heemann Betti, Amanda Danuello, Marcos Pivatto, Fernanda Bossemeyer Centurião, Camila B. Antonio, Stela Maris Kuze Rates, Vanderlan da Silva Bolzani,

Tópico(s)

Biological and pharmacological studies of plants

Resumo

Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (−)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10 mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10 mg/kg, p.o.), without impairing animals locomotor activity.

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