Produção Nacional
Revisado por pares
MCM 3 could be a better marker than K i‐67 for evaluation of dysplastic oral lesions: an immunohistochemical study
2014; Wiley; Volume: 43; Issue: 6 Linguagem: Inglês
10.1111/jop.12153
ISSN1600-0714
AutoresAladim Gomes Lameira, Flávia Sirotheau Corrêa Pontes, Douglas Magno Guimarães, Ana Carolina Garcia Alves, Adriana Souza de Jesus, Hélder Antônio Rebelo Pontes, Décio dos Santos Pinto Júnior,
Tópico(s)Salivary Gland Tumors Diagnosis and Treatment
ResumoThe aim of this study was to identify the expression of MCM3, Ki-67 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions.The samples were collected from 37 patients with oral leucoplakia (13 with mild dysplasia - MLD, 12 with moderate dysplasia - MD and 12 with severe dysplasia - SD). Eleven samples of mouth floor mucocele (M) and 50 floor mouth and tongue samples OSCC of untreated patients were included in this study. Immunohistochemical expression of MCM3, Ki-67 and p27 of all the groups was analysed. Kruskal-Wallis and Dunn's test were used to determine differences among groups, and a Pearson's correlation test was used to evaluate the correlation between the proteins.Ki-67 expression was higher in OSCC than M (P < 0.001) and MLD (P < 0.01) groups, and there was a lower expression in M compared with MD and SD (P < 0.05). Regarding p27, its expression was lower in OSCC compared with M, MD and SD. MCM3 expression was lower in M compared with SD and OSCC (P < 0.001), and MLD showed a lower expression when compared SD (P < 0.01) and OSCC (P < 0.001). Moreover, a better correlation was observed between the proteins MCM3 and p27 than between Ki-67 and p27 proteins when all lesions were examined together.This study showed that MCM3 could be a better marker than Ki-67 for evaluation of dysplastic oral lesions.
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