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Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development

1999; Elsevier BV; Volume: 84; Issue: 1-2 Linguagem: Inglês

10.1016/s0925-4773(99)00053-2

1872-6356

Alessandro Bulfone, Salvador Martı́nez, Valeria Marigo, Marilena Campanella, Andrea Basile, Nandita Quaderi, Claudio Gattuso, John L.R. Rubenstein, Andrea Ballabio,

Hedgehog Signaling Pathway Studies

The members of the T-box gene family share a highly conserved DNA binding domain named the T-domain, and important developmental functions. Here we report the cloning of chicken Tbr1and of murine and chickenTbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of expression during mouse and chick embryogenesis. Both Tbr 1 and 2 have a restricted and conserved domain of expression in the telencephalic pallium of the two species. Chick Tbr2 has a specific and dynamic expression in the gastrulating embryo.