Artigo Revisado por pares

ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians

2010; Thieme Medical Publishers (Germany); Volume: 31; Issue: 04 Linguagem: Inglês

10.1055/s-0030-1247529

ISSN

1439-3964

Autores

Natalia Bustamante‐Ara, Catalina Santiago, Zoraida Verde, Thomas Yvert, Félix Gómez‐Gallego, Gabriel Rodríguez-Romo, P. González-Gil, José Antonio Serra Rexach, Jonatan R. Ruiz, Alejandro Lucía,

Tópico(s)

Muscle metabolism and nutrition

Resumo

We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i. e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n=41, 33 women, 8 men, age: 90-97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes ( ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.

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