Portal de Periódicos da CAPES

Personal reflections on efforts to reduce ischemic myocardial damage

2002; Oxford University Press; Volume: 56; Issue: 3 Linguagem: Inglês

10.1016/s0008-6363(02)00643-0

1755-3245

Eugene Braunwald,

Cardiac electrophysiology and arrhythmias

Background mortality by half [4], leaving pump failure associated with large infarction as a major challenge in cardiology.In the second half of the 19th Century, physiologists observed that ligation of a major coronary artery in the dog was immediately fatal.During that era, pathologists occa-2 .Early research sionally encountered thrombosis of such vessels and acute myocardial infarction (AMI) at autopsy, and consideredIn 1951, as a medical student at New York University this combination of findings to be quite uncommon and and Bellevue Hospital, I was introduced to cardiovascular uniformly fatal.At the dawn of the twentieth century, research in the hemodynamic laboratory of Ludwig Eich-Krehl, a Viennese physician, challenged these beliefs and na, a pioneer in the study of human heart failure.I reported that coronary thrombosis was actually compatible participated in some of the earliest measurement of cardiac with survival [1].In 1910, Obrastov and Strazheske [2],output in patients with cardiogenic shock secondary to two Russian physicians, and in 1912, Herrick, a Chicago AMI.During a postdoctoral fellowship in the Nobel Prize physician [3], described the clinical features of AMI, winning laboratory of Professors Andre Cournand and related them to the pathologic findings and distinguished Dickinson Richards in 1954-55, on the Columbia Uni-AMI from angina pectoris.Herrick also adapted the then versity Service of Bellevue Hospital, we studied patients new technique of electrocardiography to the premorbid with chronic congestive heart failure, many of whom had diagnosis of AMI, considered at the time to be a very previously suffered a MI.Therefore, by the time that I uncommon condition.