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Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles

2010; Elsevier BV; Volume: 6; Issue: 5 Linguagem: Inglês

10.1016/j.nano.2010.02.001

1549-9642

Fidel Martínez‐Gutiérrez, Peggy L. Olive, Adriana Banuelos, E. Orrantia, Nereyda Niño‐Martínez, Elpidio Morales Sánchez, Facundo Ruíz, Horacio Bach, Yossef Av‐Gay,

Antimicrobial agents and applications

Microbial resistance represents a challenge for the scientific community to develop new bioactive compounds. Nosocomial infections represent an enormous emerging problem, especially in patients with ambulatory treatment, which requires that they wear medical devices for an extended period of time. In this work, an evaluation of the antimicrobial activity of both silver and titanium nanoparticles was carried out against a panel of selected pathogenic and opportunistic microorganisms, some of them commonly associated with device-associated infections. Cytotoxicity assays monitoring DNA damage and cell viability were evaluated using human-derived monocyte cell lines. We show that silver-coated nanoparticles having a size of 20–25 nm were the most effective among all the nanoparticles assayed against the tested microorganisms. In addition, these nanoparticles showed no significant cytotoxicity, suggesting their use as antimicrobial additives in the process of fabrication of ambulatory and nonambulatory medical devices. In this study, antimicrobial activity of silver and titanium nanoparticles was evaluated against a panel of selected pathogenic and opportunistic microorganisms. Silver-coated nanoparticles of 20–25 nm size were the most effective among all the nanoparticles without significant cytotoxicity, suggesting their use as antimicrobial additives in the process of fabrication of ambulatory and nonambulatory medical devices.