Artigo Revisado por pares

Cell Kinetic in Epithelium and Stroma of Benign Prostatic Hyperplasia

1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 1 Linguagem: Inglês

10.1097/00005392-199707000-00074

ISSN

1527-3792

Autores

Siegfried Claus, R. Berges, Theodor Senge, Harald Schulze,

Tópico(s)

Urinary Bladder and Prostate Research

Resumo

No AccessJournal of UrologyInvestigative Urology1 Jul 1997Cell Kinetic in Epithelium and Stroma of Benign Prostatic Hyperplasia Siegfried Claus, Richard Berges, Theodor Senge, and Harald Schulze Siegfried ClausSiegfried Claus , Richard BergesRichard Berges , Theodor SengeTheodor Senge , and Harald SchulzeHarald Schulze View All Author Informationhttps://doi.org/10.1097/00005392-199707000-00074AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The induction of benign prostatic hyperplasia (BPH) from normal prostate is obviously associated with a distinct increase in epithelial and stromal proliferation. We have shown previously that the further increase of BPH volume in aging men is not associated with a further increase in proliferation. We studied whether an imbalance between programmed cell death (apoptosis) and cell proliferation may explain continuing growth in aging men. In prostates of 17 men with BPH removed by open prostatectomy proliferating cells were localized immunohistochemically with the Ki-67 antibody. Apoptotic cells were detected with the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling (TUNEL) method. Proliferation and apoptotic index was calculated with a computer assisted image analysis system. Mean proliferation index +/− standard deviation in epithelium (0.142 +/− 0.097) and stroma (0.121 +/− 0.082) was nearly identical. Mean apoptotic index in epithelium (0.172 +/− 0.156) was negligibly higher than the corresponding proliferation index. In stroma, however, no apoptotic cells were detectable. Proliferation index and apoptotic index in epithelium and proliferation index in stroma showed no correlation to patient age or prostate volume. In the epithelium of BPH, obviously the cell kinetic is balanced. 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Google Scholar From the Department of Urology, University of Bochum, Herne, Germany.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMori F, Oda N, Sakuragi M, Sakakibara F, Kiniwa M and Miyoshi K (2008) New Histopathological Experimental Model for Benign Prostatic Hyperplasia: Stromal Hyperplasia in RatsJournal of Urology, VOL. 181, NO. 2, (890-898), Online publication date: 1-Feb-2009.SHARIAT S, ASHFAQ R, ROEHRBORN C, SLAWIN K and LOTAN Y (2018) EXPRESSION OF SURVIVIN AND APOPTOTIC BIOMARKERS IN BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 174, NO. 5, (2046-2050), Online publication date: 1-Nov-2005.LEE K and PEEHL D (2018) MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 172, NO. 5, (1784-1791), Online publication date: 1-Nov-2004.HEGARTY P, WATSON R, COFFEY R, WEBBER M and FITZPATRICK J (2018) Effects of Cyclic Stretch On Prostatic Cells in CultureJournal of Urology, VOL. 168, NO. 5, (2291-2295), Online publication date: 1-Nov-2002.CHUEH S, GUH J, CHEN J, LAI M and TENG C (2018) DUAL EFFECTS OF OUABAIN ON THE REGULATION OF PROLIFERATION AND APOPTOSIS IN HUMAN PROSTATIC SMOOTH MUSCLE CELLSJournal of Urology, VOL. 166, NO. 1, (347-353), Online publication date: 1-Jul-2001.MARCELLI M, SHAO T, LI X, YIN H, MARANI M, DENNER L, TENG B and CUNNINGHAM G (2018) INDUCTION OF APOPTOSIS IN BPH STROMAL CELLS BY ADENOVIRAL-MEDIATED OVEREXPRESSION OF CASPASE-7Journal of Urology, VOL. 164, NO. 2, (518-525), Online publication date: 1-Aug-2000.DE MARZO A, NELSON W, MEEKER A and COFFEY D (2018) STEM CELL FEATURES OF BENIGN AND MALIGNANT PROSTATE EPITHELIAL CELLSJournal of Urology, VOL. 160, NO. 6 Part 2, (2381-2392), Online publication date: 1-Dec-1998. Volume 158 Issue 1 July 1997 Page: 217-221 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.Metrics Author Information Siegfried Claus More articles by this author Richard Berges More articles by this author Theodor Senge More articles by this author Harald Schulze More articles by this author Expand All Advertisement PDF downloadLoading ...

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