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NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′- C -METHYLCYTIDINE

2005; Taylor & Francis; Volume: 24; Issue: 5-7 Linguagem: Inglês

10.1081/ncn-200060112

1532-2335

Claire Pierra, S. Benzaria, A. Amador, A. Moussa, Sylvain Mathieu, Richard Storer, G. Gosselin,

Influenza Virus Research Studies

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.